Can gene maps predict where Alzheimer's attacks the brain?

Researchers built a generative model combining gene expression data from 910 genes across 68 brain regions with Alzheimer's disease brain shrinkage measurements from over 1,300 people. The model predicted regional neurodegeneration with 86% accuracy, suggesting that how genes organize spatially in the brain determines which areas degenerate first. This bridges the gap between molecular biology and large-scale brain deterioration, potentially explaining why Alzheimer's attacks certain regions preferentially.