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Fast Python tool handles massive family trees without slowing down

Matthew Andres Moreno, Jeet Sukumaran, Luis Zaman, Emily Dolson

May 27, 2026

PhyloFrame represents evolutionary trees as DataFrames—tables where rows are organisms and columns track ancestry, branch lengths, and traits. This design unlocks speed through parallel processing and compression while keeping code simple enough for interactive analysis. Researchers can now query, filter, and visualize massive trees using standard data science libraries instead than wrestling with slow, inflexible specialized tools.
Published as PhyloFrame: A DataFrame-based Library for Fast, Flexible Phylogenetic Computation arXiv:2605.28545
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